CTNNB1, catenin beta 1, 1499

N. diseases: 1368; N. variants: 68
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.600 Biomarker disease BEFREE δ-Catenin, a member of the p120-catenin subfamily of armadillo proteins, reportedly increases during the late stage of prostate cancer. 29629558 2018
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.100 Biomarker disease BEFREE δ-Catenin, a member of the p120-catenin subfamily of armadillo proteins, reportedly increases during the late stage of prostate cancer. 29629558 2018
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.100 Biomarker disease BEFREE γ-Tocotrienol inhibits cell viability through suppression of β-catenin/Tcf signaling in human colon carcinoma HT-29 cells. 21852086 2012
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.400 Biomarker disease BEFREE γ-Catenin at adherens junctions: mechanism and biologic implications in hepatocellular cancer after β-catenin knockdown. 23555187 2013
CUI: C0279606
Disease: Childhood Hepatocellular Carcinoma
Childhood Hepatocellular Carcinoma 		0.330 Biomarker disease BEFREE γ-Catenin at adherens junctions: mechanism and biologic implications in hepatocellular cancer after β-catenin knockdown. 23555187 2013
CUI: C0279607
Disease: Adult Hepatocellular Carcinoma
Adult Hepatocellular Carcinoma 		0.330 Biomarker disease BEFREE γ-Catenin at adherens junctions: mechanism and biologic implications in hepatocellular cancer after β-catenin knockdown. 23555187 2013
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.400 Biomarker disease BEFREE β2 spectrin-mediated differentiation repressed the properties of liver cancer stem cells through β-catenin. 29555987 2018
CUI: C0220630
Disease: Adult Liver Carcinoma
Adult Liver Carcinoma 		0.100 Biomarker disease BEFREE β2 spectrin-mediated differentiation repressed the properties of liver cancer stem cells through β-catenin. 29555987 2018
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.100 Biomarker disease BEFREE β2 spectrin-mediated differentiation repressed the properties of liver cancer stem cells through β-catenin. 29555987 2018
CUI: C0220668
Disease: Congenital contractural arachnodactyly
Congenital contractural arachnodactyly 		0.040 Biomarker disease BEFREE β-escin was a potent reverser of P-gp-dependent multidrug resistance, with said effect likely being achieved via inhibition of the GSK3β/β-catenin pathway and thus suggesting a promising strategy of developing combination drugs for CCA. 25632187 2015
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma 		0.100 Biomarker disease BEFREE β-escin reverses multidrug resistance through inhibition of the GSK3β/β-catenin pathway in cholangiocarcinoma. 25632187 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 Biomarker disease PSYGENET β-catenin promoter ChIP-chip reveals potential schizophrenia and bipolar disorder gene network. 20615089 2010
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.700 Biomarker disease BEFREE β-Arrestins (Arrb) participate in the regulation of multiple signaling pathways, including Wnt/β-catenin, the major actor in human colorectal cancer initiation. 22315403 2012
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 Biomarker disease BEFREE β-Arrestins (Arrb) participate in the regulation of multiple signaling pathways, including Wnt/β-catenin, the major actor in human colorectal cancer initiation. 22315403 2012
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.400 AlteredExpression disease BEFREE α-Actinin-4 induces the epithelial-to-mesenchymal transition and tumorigenesis via regulation of Snail expression and β-catenin stabilization in cervical cancer. 27065319 2016
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.100 AlteredExpression disease BEFREE α-Actinin-4 induces the epithelial-to-mesenchymal transition and tumorigenesis via regulation of Snail expression and β-catenin stabilization in cervical cancer. 27065319 2016
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.100 AlteredExpression disease BEFREE α-Actinin-4 induces the epithelial-to-mesenchymal transition and tumorigenesis via regulation of Snail expression and β-catenin stabilization in cervical cancer. 27065319 2016
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.100 AlteredExpression disease LHGDN [The specific features of the expression of E-cadherin and beta-catenin in adenomyosis]. 19137776 2009
CUI: C3554449
Disease: MENTAL RETARDATION, AUTOSOMAL DOMINANT 19
MENTAL RETARDATION, AUTOSOMAL DOMINANT 19 		0.700 CausalMutation disease CLINVAR [Intraoperative echocardiographic assessment of left ventricular muscle volume changes after intracardiac operation under cardiopulmonary bypass]. 2614104 1989
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy 		0.110 CausalMutation disease CLINVAR [Intraoperative echocardiographic assessment of left ventricular muscle volume changes after intracardiac operation under cardiopulmonary bypass]. 2614104 1989
CUI: C0036857
Disease: Severe intellectual disability
Severe intellectual disability 		0.110 CausalMutation disease CLINVAR [Intraoperative echocardiographic assessment of left ventricular muscle volume changes after intracardiac operation under cardiopulmonary bypass]. 2614104 1989
CUI: C0013362
Disease: Dysarthria
Dysarthria 		0.100 CausalMutation disease CLINVAR [Intraoperative echocardiographic assessment of left ventricular muscle volume changes after intracardiac operation under cardiopulmonary bypass]. 2614104 1989
CUI: C0023882
Disease: Little's Disease
Little's Disease 		0.100 CausalMutation disease CLINVAR [Intraoperative echocardiographic assessment of left ventricular muscle volume changes after intracardiac operation under cardiopulmonary bypass]. 2614104 1989
CUI: C1845245
Disease: Lower limb hypertonia
Lower limb hypertonia 		0.100 CausalMutation phenotype CLINVAR [Intraoperative echocardiographic assessment of left ventricular muscle volume changes after intracardiac operation under cardiopulmonary bypass]. 2614104 1989
CUI: C3887926
Disease: CATARACT 32, MULTIPLE TYPES
CATARACT 32, MULTIPLE TYPES 		0.100 CausalMutation disease CLINVAR [Intraoperative echocardiographic assessment of left ventricular muscle volume changes after intracardiac operation under cardiopulmonary bypass]. 2614104 1989